08 Apr 2022
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You can absolutely setup a Sandbox CRM to use with the dev portal. As far as best practices, it would mostly be ensuring the 2 CRM's match as closely as possible so testing can be consistent. Outside of that, the connection/configurations would essentially be the same.
A great way to ensure consistency is copying the environments. That way when changing connections, you don't lose entity metadata, etc.
Here is a link to some docs for copying environments: https://docs.microsoft.com/en-us/power-platform/admin/copy-environment
I'm not sure if that answers your question but please feel free to elaborate further and I will do my best to provide you with more information.
Kind regards,
Brady
TPC Web Developer